diff --git a/packages/babel-plugin-transform-es2015-modules-commonjs/test/fixtures/interop/imports-hoisting/expected.js b/packages/babel-plugin-transform-es2015-modules-commonjs/test/fixtures/interop/imports-hoisting/expected.js
index c48d60f6e2..3fe83b718c 100644
--- a/packages/babel-plugin-transform-es2015-modules-commonjs/test/fixtures/interop/imports-hoisting/expected.js
+++ b/packages/babel-plugin-transform-es2015-modules-commonjs/test/fixtures/interop/imports-hoisting/expected.js
@@ -1,9 +1,5 @@
-"use strict";
+var _taggedTemplateLiteral = require("babel-runtime/helpers/taggedTemplateLiteral").default;
 
-var _taggedTemplateLiteral2 = _interopRequireDefault(require("babel-runtime/helpers/taggedTemplateLiteral"));
-
-var _templateObject = (0, _taggedTemplateLiteral2.default)(["foo"], ["foo"]);
-
-function _interopRequireDefault(obj) { return obj && obj.__esModule ? obj : { default: obj }; }
+var _templateObject = _taggedTemplateLiteral(["foo"], ["foo"]);
 
 tag(_templateObject);
diff --git a/packages/babel-plugin-transform-es2015-modules-commonjs/test/fixtures/interop/multi-load/actual.js b/packages/babel-plugin-transform-es2015-modules-commonjs/test/fixtures/interop/multi-load/actual.js
new file mode 100644
index 0000000000..c21dca024a
--- /dev/null
+++ b/packages/babel-plugin-transform-es2015-modules-commonjs/test/fixtures/interop/multi-load/actual.js
@@ -0,0 +1,3 @@
+export {};
+
+console.log(helper);
diff --git a/packages/babel-plugin-transform-es2015-modules-commonjs/test/fixtures/interop/multi-load/expected.js b/packages/babel-plugin-transform-es2015-modules-commonjs/test/fixtures/interop/multi-load/expected.js
new file mode 100644
index 0000000000..a25580a1aa
--- /dev/null
+++ b/packages/babel-plugin-transform-es2015-modules-commonjs/test/fixtures/interop/multi-load/expected.js
@@ -0,0 +1,7 @@
+"use strict";
+
+var _interopRequireDefault3 = require("babel-runtime/helpers/interopRequireDefault").default;
+
+var _interopRequireDefault2 = _interopRequireDefault3(require("babel-runtime/helpers/interopRequireDefault"));
+
+console.log(_interopRequireDefault2.default);
diff --git a/packages/babel-plugin-transform-es2015-modules-commonjs/test/fixtures/interop/multi-load/options.json b/packages/babel-plugin-transform-es2015-modules-commonjs/test/fixtures/interop/multi-load/options.json
new file mode 100644
index 0000000000..a967c87acd
--- /dev/null
+++ b/packages/babel-plugin-transform-es2015-modules-commonjs/test/fixtures/interop/multi-load/options.json
@@ -0,0 +1,7 @@
+{
+  "plugins": [
+    "transform-es2015-modules-commonjs",
+    "transform-runtime",
+    "./plugin"
+  ]
+}
diff --git a/packages/babel-plugin-transform-es2015-modules-commonjs/test/fixtures/interop/multi-load/plugin.js b/packages/babel-plugin-transform-es2015-modules-commonjs/test/fixtures/interop/multi-load/plugin.js
new file mode 100644
index 0000000000..22a13dab2d
--- /dev/null
+++ b/packages/babel-plugin-transform-es2015-modules-commonjs/test/fixtures/interop/multi-load/plugin.js
@@ -0,0 +1,11 @@
+module.exports = function() {
+  return {
+    visitor: {
+      Identifier: function(path) {
+        if (path.node.name !== "helper") return;
+
+        path.replaceWith(this.addHelper("interopRequireDefault"));
+      },
+    },
+  };
+};
diff --git a/packages/babel-plugin-transform-regenerator/test/fixtures/regression/T7041/expected.js b/packages/babel-plugin-transform-regenerator/test/fixtures/regression/T7041/expected.js
index a92d32a6a9..db75009829 100644
--- a/packages/babel-plugin-transform-regenerator/test/fixtures/regression/T7041/expected.js
+++ b/packages/babel-plugin-transform-regenerator/test/fixtures/regression/T7041/expected.js
@@ -1,19 +1,15 @@
-"use strict";
+var _regeneratorRuntime = require("babel-runtime/regenerator").default;
 
-var _regenerator = _interopRequireDefault(require("babel-runtime/regenerator"));
-
-var _keys = _interopRequireDefault(require("babel-runtime/core-js/object/keys"));
-
-function _interopRequireDefault(obj) { return obj && obj.__esModule ? obj : { default: obj }; }
+var _Object$keys = require("babel-runtime/core-js/object/keys").default;
 
 var _marked =
 /*#__PURE__*/
-_regenerator.default.mark(fn);
+_regeneratorRuntime.mark(fn);
 
-(0, _keys.default)({});
+_Object$keys({});
 
 function fn() {
-  return _regenerator.default.wrap(function fn$(_context) {
+  return _regeneratorRuntime.wrap(function fn$(_context) {
     while (1) {
       switch (_context.prev = _context.next) {
         case 0:
diff --git a/packages/babel-plugin-transform-runtime/package.json b/packages/babel-plugin-transform-runtime/package.json
index c153cba2ff..0ec49afe6f 100644
--- a/packages/babel-plugin-transform-runtime/package.json
+++ b/packages/babel-plugin-transform-runtime/package.json
@@ -8,6 +8,9 @@
   "keywords": [
     "babel-plugin"
   ],
+  "dependencies": {
+    "babel-helper-module-imports": "7.0.0-beta.2"
+  },
   "devDependencies": {
     "babel-helper-plugin-test-runner": "7.0.0-beta.2"
   }
diff --git a/packages/babel-plugin-transform-runtime/src/index.js b/packages/babel-plugin-transform-runtime/src/index.js
index 7fb4f15ed8..fff182e7a3 100644
--- a/packages/babel-plugin-transform-runtime/src/index.js
+++ b/packages/babel-plugin-transform-runtime/src/index.js
@@ -1,3 +1,5 @@
+import { addDefault, isModule } from "babel-helper-module-imports";
+
 import definitions from "./definitions";
 
 export default function({ types: t }) {
@@ -9,7 +11,7 @@ export default function({ types: t }) {
     return Object.prototype.hasOwnProperty.call(obj, key);
   }
 
-  const HELPER_BLACKLIST = ["interopRequireWildcard", "interopRequireDefault"];
+  const HEADER_HELPERS = ["interopRequireWildcard", "interopRequireDefault"];
 
   return {
     pre(file) {
@@ -23,12 +25,19 @@ export default function({ types: t }) {
           ? `${baseHelpersDir}/es6`
           : baseHelpersDir;
         file.set("helperGenerator", name => {
-          if (HELPER_BLACKLIST.indexOf(name) < 0) {
-            return this.addDefaultImport(
-              `${moduleName}/${helpersDir}/${name}`,
-              name,
-            );
-          }
+          const isInteropHelper = HEADER_HELPERS.indexOf(name) !== -1;
+
+          // Explicitly set the CommonJS interop helpers to their reserve
+          // blockHoist of 4 so they are guaranteed to exist
+          // when other things used them to import.
+          const blockHoist =
+            isInteropHelper && !isModule(file.path) ? 4 : undefined;
+
+          return this.addDefaultImport(
+            `${moduleName}/${helpersDir}/${name}`,
+            name,
+            blockHoist,
+          );
         });
       }
 
@@ -40,8 +49,28 @@ export default function({ types: t }) {
 
       this.moduleName = moduleName;
 
-      this.addDefaultImport = (source, nameHint) => {
-        return file.addImport(source, "default", nameHint);
+      const cache = new Map();
+
+      this.addDefaultImport = (source, nameHint, blockHoist) => {
+        // If something on the page adds a helper when the file is an ES6
+        // file, we can't reused the cached helper name after things have been
+        // transformed because it has almost certainly been renamed.
+        const cacheKey = isModule(file.path);
+        const key = `${source}:${nameHint}:${cacheKey || ""}`;
+
+        let cached = cache.get(key);
+        if (cached) {
+          cached = t.cloneDeep(cached);
+        } else {
+          cached = addDefault(file.path, source, {
+            importedInterop: "compiled",
+            nameHint,
+            blockHoist,
+          });
+
+          cache.set(key, cached);
+        }
+        return cached;
       };
     },
 
diff --git a/packages/babel-plugin-transform-runtime/test/fixtures/runtime/aliased-constructors/expected.js b/packages/babel-plugin-transform-runtime/test/fixtures/runtime/aliased-constructors/expected.js
index 1cb089296d..e9af3f9463 100644
--- a/packages/babel-plugin-transform-runtime/test/fixtures/runtime/aliased-constructors/expected.js
+++ b/packages/babel-plugin-transform-runtime/test/fixtures/runtime/aliased-constructors/expected.js
@@ -1,6 +1,9 @@
-import _Map from "babel-runtime/core-js/map";
-import _Symbol from "babel-runtime/core-js/symbol";
-import _Promise from "babel-runtime/core-js/promise";
+var _Map = require("babel-runtime/core-js/map").default;
+
+var _Symbol = require("babel-runtime/core-js/symbol").default;
+
+var _Promise = require("babel-runtime/core-js/promise").default;
+
 obj.constructor === Object;
 obj.constructor === _Promise;
 
diff --git a/packages/babel-plugin-transform-runtime/test/fixtures/runtime/catch-all/expected.js b/packages/babel-plugin-transform-runtime/test/fixtures/runtime/catch-all/expected.js
index 97b8bf8e3b..dfe1f85728 100644
--- a/packages/babel-plugin-transform-runtime/test/fixtures/runtime/catch-all/expected.js
+++ b/packages/babel-plugin-transform-runtime/test/fixtures/runtime/catch-all/expected.js
@@ -1,2 +1,3 @@
-import _Promise from "babel-runtime/core-js/promise";
+var _Promise = require("babel-runtime/core-js/promise").default;
+
 _Promise.resolve;
diff --git a/packages/babel-plugin-transform-runtime/test/fixtures/runtime/class/expected.js b/packages/babel-plugin-transform-runtime/test/fixtures/runtime/class/expected.js
index 698463f783..62f7026093 100644
--- a/packages/babel-plugin-transform-runtime/test/fixtures/runtime/class/expected.js
+++ b/packages/babel-plugin-transform-runtime/test/fixtures/runtime/class/expected.js
@@ -1,4 +1,4 @@
-import _classCallCheck from "babel-runtime/helpers/classCallCheck";
+var _classCallCheck = require("babel-runtime/helpers/classCallCheck").default;
 
 let Foo = function Foo() {
   _classCallCheck(this, Foo);
diff --git a/packages/babel-plugin-transform-runtime/test/fixtures/runtime/es6-for-of/expected.js b/packages/babel-plugin-transform-runtime/test/fixtures/runtime/es6-for-of/expected.js
index 838e15fd3d..2b6d04b822 100644
--- a/packages/babel-plugin-transform-runtime/test/fixtures/runtime/es6-for-of/expected.js
+++ b/packages/babel-plugin-transform-runtime/test/fixtures/runtime/es6-for-of/expected.js
@@ -1,4 +1,5 @@
-import _getIterator from "babel-runtime/core-js/get-iterator";
+var _getIterator = require("babel-runtime/core-js/get-iterator").default;
+
 var _iteratorNormalCompletion = true;
 var _didIteratorError = false;
 var _iteratorError = undefined;
diff --git a/packages/babel-plugin-transform-runtime/test/fixtures/runtime/modules-helpers/actual.mjs b/packages/babel-plugin-transform-runtime/test/fixtures/runtime/modules-helpers/actual.mjs
new file mode 100644
index 0000000000..368b106310
--- /dev/null
+++ b/packages/babel-plugin-transform-runtime/test/fixtures/runtime/modules-helpers/actual.mjs
@@ -0,0 +1,5 @@
+import foo from "foo";
+
+class Example {
+  method() {}
+}
diff --git a/packages/babel-plugin-transform-runtime/test/fixtures/runtime/modules-helpers/expected.js b/packages/babel-plugin-transform-runtime/test/fixtures/runtime/modules-helpers/expected.js
new file mode 100644
index 0000000000..853c42e84b
--- /dev/null
+++ b/packages/babel-plugin-transform-runtime/test/fixtures/runtime/modules-helpers/expected.js
@@ -0,0 +1,23 @@
+"use strict";
+
+var _interopRequireDefault = require("babel-runtime/helpers/interopRequireDefault").default;
+
+var _classCallCheck2 = _interopRequireDefault(require("babel-runtime/helpers/classCallCheck"));
+
+var _createClass2 = _interopRequireDefault(require("babel-runtime/helpers/createClass"));
+
+var _foo = _interopRequireDefault(require("foo"));
+
+let Example =
+/*#__PURE__*/
+function () {
+  function Example() {
+    (0, _classCallCheck2.default)(this, Example);
+  }
+
+  (0, _createClass2.default)(Example, [{
+    key: "method",
+    value: function method() {}
+  }]);
+  return Example;
+}();
diff --git a/packages/babel-plugin-transform-runtime/test/fixtures/runtime/modules-helpers/options.json b/packages/babel-plugin-transform-runtime/test/fixtures/runtime/modules-helpers/options.json
new file mode 100644
index 0000000000..304a7fdde2
--- /dev/null
+++ b/packages/babel-plugin-transform-runtime/test/fixtures/runtime/modules-helpers/options.json
@@ -0,0 +1,7 @@
+{
+  "plugins": [
+    "transform-runtime",
+    "transform-es2015-modules-commonjs",
+    "transform-es2015-classes"
+  ]
+}
diff --git a/packages/babel-plugin-transform-runtime/test/fixtures/runtime/modules/expected.js b/packages/babel-plugin-transform-runtime/test/fixtures/runtime/modules/expected.js
index fef9aa0bb8..742c943e04 100644
--- a/packages/babel-plugin-transform-runtime/test/fixtures/runtime/modules/expected.js
+++ b/packages/babel-plugin-transform-runtime/test/fixtures/runtime/modules/expected.js
@@ -1,7 +1,11 @@
 "use strict";
 
-import _Object$defineProperty from "babel-runtime/core-js/object/define-property";
-import _Object$keys from "babel-runtime/core-js/object/keys";
+var _interopRequireDefault = require("babel-runtime/helpers/interopRequireDefault").default;
+
+var _Object$defineProperty = require("babel-runtime/core-js/object/define-property").default;
+
+var _Object$keys = require("babel-runtime/core-js/object/keys").default;
+
 Object.defineProperty(exports, "__esModule", {
   value: true
 });
@@ -21,6 +25,4 @@ _Object$keys(_mod).forEach(function (key) {
   });
 });
 
-function _interopRequireDefault(obj) { return obj && obj.__esModule ? obj : { default: obj }; }
-
 _bar.default;
diff --git a/packages/babel-plugin-transform-runtime/test/fixtures/runtime/regenerator-runtime/expected.js b/packages/babel-plugin-transform-runtime/test/fixtures/runtime/regenerator-runtime/expected.js
index a5046aeb3b..af1647cc2e 100644
--- a/packages/babel-plugin-transform-runtime/test/fixtures/runtime/regenerator-runtime/expected.js
+++ b/packages/babel-plugin-transform-runtime/test/fixtures/runtime/regenerator-runtime/expected.js
@@ -1,4 +1,5 @@
-import _regeneratorRuntime from "babel-runtime/regenerator";
+var _regeneratorRuntime = require("babel-runtime/regenerator").default;
+
 void
 /*#__PURE__*/
 _regeneratorRuntime.mark(function _callee() {
diff --git a/packages/babel-plugin-transform-runtime/test/fixtures/runtime/symbol-iterator-in/expected.js b/packages/babel-plugin-transform-runtime/test/fixtures/runtime/symbol-iterator-in/expected.js
index 97b293263d..c426027195 100644
--- a/packages/babel-plugin-transform-runtime/test/fixtures/runtime/symbol-iterator-in/expected.js
+++ b/packages/babel-plugin-transform-runtime/test/fixtures/runtime/symbol-iterator-in/expected.js
@@ -1,3 +1,3 @@
-import _isIterable from "babel-runtime/core-js/is-iterable";
+var _isIterable = require("babel-runtime/core-js/is-iterable").default;
 
 _isIterable(Object(arr));
diff --git a/packages/babel-plugin-transform-runtime/test/fixtures/runtime/symbol-iterator/expected.js b/packages/babel-plugin-transform-runtime/test/fixtures/runtime/symbol-iterator/expected.js
index 5b72708826..0d5b32855c 100644
--- a/packages/babel-plugin-transform-runtime/test/fixtures/runtime/symbol-iterator/expected.js
+++ b/packages/babel-plugin-transform-runtime/test/fixtures/runtime/symbol-iterator/expected.js
@@ -1,2 +1,3 @@
-import _Symbol$iterator from "babel-runtime/core-js/symbol/iterator";
+var _Symbol$iterator = require("babel-runtime/core-js/symbol/iterator").default;
+
 _Symbol$iterator;
diff --git a/packages/babel-plugin-transform-runtime/test/fixtures/use-options/useBuiltIns-useESModules/expected.js b/packages/babel-plugin-transform-runtime/test/fixtures/use-options/useBuiltIns-useESModules/expected.js
index 17c83a4dc1..06770b5e0d 100644
--- a/packages/babel-plugin-transform-runtime/test/fixtures/use-options/useBuiltIns-useESModules/expected.js
+++ b/packages/babel-plugin-transform-runtime/test/fixtures/use-options/useBuiltIns-useESModules/expected.js
@@ -1,6 +1,8 @@
-import _classCallCheck from "babel-runtime/helpers/builtin/es6/classCallCheck";
-import _possibleConstructorReturn from "babel-runtime/helpers/builtin/es6/possibleConstructorReturn";
-import _inherits from "babel-runtime/helpers/builtin/es6/inherits";
+var _classCallCheck = require("babel-runtime/helpers/builtin/es6/classCallCheck").default;
+
+var _possibleConstructorReturn = require("babel-runtime/helpers/builtin/es6/possibleConstructorReturn").default;
+
+var _inherits = require("babel-runtime/helpers/builtin/es6/inherits").default;
 
 let Foo =
 /*#__PURE__*/
diff --git a/packages/babel-plugin-transform-runtime/test/fixtures/use-options/useBuiltIns/expected.js b/packages/babel-plugin-transform-runtime/test/fixtures/use-options/useBuiltIns/expected.js
index 6213695eff..cfdbd19017 100644
--- a/packages/babel-plugin-transform-runtime/test/fixtures/use-options/useBuiltIns/expected.js
+++ b/packages/babel-plugin-transform-runtime/test/fixtures/use-options/useBuiltIns/expected.js
@@ -1,6 +1,8 @@
-import _classCallCheck from "babel-runtime/helpers/builtin/classCallCheck";
-import _possibleConstructorReturn from "babel-runtime/helpers/builtin/possibleConstructorReturn";
-import _inherits from "babel-runtime/helpers/builtin/inherits";
+var _classCallCheck = require("babel-runtime/helpers/builtin/classCallCheck").default;
+
+var _possibleConstructorReturn = require("babel-runtime/helpers/builtin/possibleConstructorReturn").default;
+
+var _inherits = require("babel-runtime/helpers/builtin/inherits").default;
 
 let Foo =
 /*#__PURE__*/
diff --git a/packages/babel-plugin-transform-runtime/test/fixtures/use-options/useESModules/expected.js b/packages/babel-plugin-transform-runtime/test/fixtures/use-options/useESModules/expected.js
index 4c28b4f76e..3a7695f281 100644
--- a/packages/babel-plugin-transform-runtime/test/fixtures/use-options/useESModules/expected.js
+++ b/packages/babel-plugin-transform-runtime/test/fixtures/use-options/useESModules/expected.js
@@ -1,7 +1,10 @@
-import _Object$getPrototypeOf from "babel-runtime/core-js/object/get-prototype-of";
-import _classCallCheck from "babel-runtime/helpers/es6/classCallCheck";
-import _possibleConstructorReturn from "babel-runtime/helpers/es6/possibleConstructorReturn";
-import _inherits from "babel-runtime/helpers/es6/inherits";
+var _Object$getPrototypeOf = require("babel-runtime/core-js/object/get-prototype-of").default;
+
+var _classCallCheck = require("babel-runtime/helpers/es6/classCallCheck").default;
+
+var _possibleConstructorReturn = require("babel-runtime/helpers/es6/possibleConstructorReturn").default;
+
+var _inherits = require("babel-runtime/helpers/es6/inherits").default;
 
 let Foo =
 /*#__PURE__*/